Organic radical contrast agents for magnetic resonance imaging.
نویسندگان
چکیده
We report a molecular design that provides an intravenously injectable organic radical contrast agent (ORCA) for which the molecular (1)H water relaxivity (r(1)) is ca. 5 mM(-1) s(-1). The ORCA is based on spirocyclohexyl nitroxide radicals and poly(ethylene glycol) chains conjugated to a fourth-generation polypropylenimine dendrimer scaffold. The metal-free ORCA has a long shelf life and provides selectively enhanced magnetic resonance imaging in mice for over 1 h.
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 134 38 شماره
صفحات -
تاریخ انتشار 2012